Adults of different ages walking and cycling beside the River Thames

Professor Lee’s joint repair and regeneration hub

Protect the movementthat makes life yours.

Cartilage, tendon and meniscus fail for different reasons. Professor Paul Lee’s NANO techniques share one fixed design principle—Seed · Soil · Signal—but change the biology, mechanics and delivery for the tissue being repaired.

Cartilage · NANO ACiTendon · NANO ATiMeniscus · NANO AMi
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The shared NANO logic

One organising method. Three different tissue problems.

Seed · Soil · Signal is the common grammar. The cell source, target anatomy, mechanics and recovery change with the tissue.

Three anatomical knee illustrations showing healthy articular cartilage, early-to-moderate thinning and fibrillation, and advanced diffuse cartilage wear with narrowing of the joint space

NANO ACi

Cartilage

Cartilage wear or damage

Three anatomical Achilles tendon illustrations showing healthy parallel collagen fibres, chronic tendinopathy with thickening and fibre disorganisation, and a partial-thickness tear with remaining tendon continuity

NANO ATi

Tendon

Disrupted collagen fibres

Medical illustrations showing intact menisci distributing load, a representative radial tear concentrating load, and meniscal tissue deficiency increasing pressure on adjacent cartilage

NANO AMi

Meniscus

Load-sharing tear

  1. 01

    Select target tissue

  2. 02

    Harvest seed

  3. 03

    Prepare soil

  4. 04

    Add signal

  5. 05

    Deliver precisely

  6. 06

    Protect and measure recovery

Begin with the tissue—not the product

Three tissues. Three repair problems. Three distinct techniques.

“Regeneration” can sound like one category of injection. Professor Lee’s approach is more exact. Cartilage needs a new surface; tendon needs organised force transmission; and the meniscus must preserve its load-sharing role.

The shared principle is a way of designing surgery: choose a tissue-relevant cellular seed, give it an environment, supply a biological signal and deliver it precisely. What changes from page to page is the part that matters most—the tissue itself.

Woman gardening comfortably with her granddaughter

Cartilage

NANO ACi

Rebuild the joint surface without taking the patient through a cartilage operation.

Woman returning confidently to recreational tennis

Tendon

NANO ATi

Bring a tissue-specific repair environment to a tendon that has stopped healing.

Man and daughter walking confidently on an uneven woodland trail

Meniscus

NANO AMi

Treat suitable stable meniscal damage without surgery while preserving the knee's load-sharing tissue.

The shared design principle

Seed. Soil. Signal. Precision.

Tissue

Cartilage

Cellular seed

Auricular-cartilage micrografts via Mytocel AMT

Soil

ChondroFiller

Signal

ArthroZheal PRF

Precision

A new environment at the joint surface

Tissue

Tendon

Cellular seed

Tendon-focused autologous micrografts via Mytocel AMT

Soil

ChondroFiller

Signal

ArthroZheal PRF

Precision

The damaged tendon zone inside a loading plan

Tissue

Meniscus

Cellular seed

Meniscus-focused autologous micrografts via Mytocel AMT

Soil

ChondroFiller

Signal

ArthroZheal PRF

Precision

The tear, remaining tissue and whole-knee mechanics

Dedicated pathway

Cartilage repair and regeneration

Cartilage has its own hub because patients may need established ACI, MACI, osteochondral grafting, ChondroFiller or Professor Lee’s NANO ACi technique. The hub separates each option and shows where it fits before replacement.

Explore the cartilage hub

The wider repertoire

Repair does not compete with replacement

Professor Lee remains a replacement and revision surgeon. Joint preservation is a question of timing: save viable tissue when that is realistic, and use replacement when it is the strongest answer—not because the treatment catalogue stops there.

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Evidence boundary

Each complete technique must earn its own authority

Mytocel AMT, ChondroFiller and ArthroZheal each have their own evidence bases. Professor Lee’s NANO techniques are defined combinations with tissue-specific selection, preparation and delivery. Evidence for a component is useful context; it is not silently converted into proof of every combined protocol.

FAQ

Questions about joint repair and regeneration

The hub is designed to make the tissue differences clear before any individual procedure is considered.

Repair restores a damaged structure; regeneration aims to rebuild or improve the biological tissue itself. Professor Lee’s plans may use either or both, depending on what has failed and what the joint can still preserve.
No. They share Professor Lee’s fixed Seed · Soil · Signal design principle, but the target tissue, micrograft source, mechanics, delivery and recovery plan change for cartilage, tendon and meniscus.
No. A torn structure may still need sutures or reattachment, and an end-stage joint may need replacement. Professor Lee uses repair and regeneration inside a complete orthopaedic repertoire.
The decision starts with diagnosis, imaging, alignment, stability, tissue quality, loading and the patient’s goals. The newest option is not automatically the right option.

Start with what has failed—and what can still be saved

The right answer may preserve, repair, regenerate or replace

cartilagetendonmeniscuswhole-joint planning

Professor Lee’s role is to match the technique to the tissue, the mechanics and the person—not to force every joint into the same pathway.

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